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Proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy may be modulated by the interconversion of glutamate, ornithine, and proline, among which proline is the key amino acid (98)

Nonpharmacologic treatment options with published evidence of efficacy in patients with CIPN include chemotherapy dose reduction, discontinuation of the offending chemotherapeutic agent(s), acupuncture, avoiding cold temperatures/maintaining warmth, physical activity, and massaging affected areas ( TABLE 3 )

Methylation is also involved in the recycling of glutathione, which is required to eliminate free radicals and harmful substances from the body

Schmidt M, Pfetzer N, Schwab M, Strauss I, Kmmerer U

7 Therapeutic strategies and clinical translation With the deepening understanding of ferroptosis mechanisms, an increasing number of molecular targets have been identified as closely associated with the pathological progression of AD