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Results: Simulated decreases in FI or DNL/FAO resulted in comparable reductions in liver fat, alanine aminotransferases (ALT), NAFLD Activity Score (NAS)

Patients were identified with suspected AATD (1 inpatient or 2 outpatient ICD-9/10-CM AATD codes 90 days apart, serum AAT 1.5 and a q-value 18%), no recommendation has been published to date for its use during follow-up

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Wu Q, R Burghardt, S Safe (2004) Page 244 and 245: B

Under low glutamine conditions, targeting ASCT2 renders breast cancer cells more sensitive to leucine uptake inhibition, suggesting that cancer cells with reduced transporter plasticity are more vulnerable to disruptions in amino acid homeostasis ( 3.6 Regulation of autophagy and apoptosis BCAA metabolism also helps tumor cells resist therapeutic pressure by influencing autophagy and apoptosis pathways