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doi: 10.1016/j.celrep.2019.02.063 148 JacobFSalinasRDZhangDYNguyenPTTSchnollJGWongSZHet al

[Google Scholar] Heijtz R

Mechanism of metformin regulation in central nervous system: Progression and future perspectives

According to a recent review, the NLRP3 inflammasome plays a crucial role in endothelial dysfunction, with its activation triggered by factors such as ROS, ischemia, and high glucose, leading to inflammation and endothelial injury [170]