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Documentation should clearly justify why an injection was required

While the IOM had based B12 needs on the amount required to correct hematological parameters for people with pernicious anemia, the EFSA had almost 20 more years of research to draw on, and concluded that the most suitable approach was basing needs on biomarkers (serum B12, holotranscobalamin, MMA, and homocysteine)

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Moreover, interventions that broadly suppress microglial activity risk impairing their essential physiological functions, including synaptic pruning, neurogenesis regulation, and clearance of cellular debris [490492]