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[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Haberle J

doi: 10.1007/s11011-014-9550-3 157 Carmona-RiveraCZhaoWYalavarthiSKaplanMJ

Taken together, copper and ROS can synergistically regulate different signaling pathways associated to tumorigenesis and tumor progression

First, the regulatory network of ferroptosis is extremely complex, involving interactions among iron metabolism, lipid chemistry, ROS generation and scavenging systems, and multiple signaling pathways