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2022;11(2):296 Segura-Aguilar J

Lyophilized peptides, those freeze-dried powders that arrive in your research supplies, are remarkably stable compounds

Microbiol., 7, 849-867 5

This would explain why the E locus is epistatic to both the B and A loci: horses of genotype ee, ee a and e a e a are chestnut regardless of their genotype at the other two loci (see the diagram below)