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doi: 10.1097/00004647-200205000-00010 188 Pralhada RaoR.VaidyanathanN.RengasamyM.Mammen OommenA.SomaiyaN.JagannathM

Cyclic peptide conformation supports stable receptor binding Conserved residues facilitate interaction with transmembrane domains Structural rigidity enhances resistance to enzymatic degradation Moreover, in vitro receptor profiling confirms sustained receptor activation following ligand engagement