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Furthermore, combination therapies that target multiple metabolic pathways, including glutamine metabolism, may enhance treatment outcomes and overcome resistance

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Further data showed macrophage functional pattern changes with duration of stimuli and that they are capable of completely changing their phenotype based on the surrounding microenvironment (135, 141, 142)

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A biomimetic nanoplatform (CuX-P) has demonstrated potentials for the treatment of TNBC by integrating cuproptosis induction, photothermal therapy, and immunotherapy