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Therapeutic implications Nrf2 Activators and NLRP3 Inhibitors as Therapeutic Agents in PD Nrf2 activators and NLRP 3 inhibitors have shown encouraging neuroprotective effects in preclinical models of PD

Formula:C 20 H 32 N 6 O 12 S 2 InChI:InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/t9-,10-,11-,12-/m0/s1 InChI key:InChIKey=YPZRWBKMTBYPTK-BJDJZHNGSA-N SMILES:[C@@H](NC(CC[C@@H](C(O)=O)N)=O)(C(NCC(O)=O)=O)CSSC[C@H](NC(CC[C@@H](C(O)=O)N)=O)C(NCC(O)=O)=O Synonyms: Glutamine, N,N'-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di- Glutamine, N,N'-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di-, L- Glutamine, N,N-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di-, L- Glutathione disulphide Glutathione, disulfide Glutathione, oxidized Glutathione-S-S-glutathione Glutathione-SSG Glutathone disulfide Glycine, L--glutamyl-L-cysteinyl-, bimol

Dysregulation will persist to enhance autoreactive T cell activation and lead to disease progression and exacerbation ( Changes in the gut microbiota can significantly impact the production of short-chain fatty acids (SCFAs) and other metabolites which in turn modulate systemic inflammation and immunity

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doi: 10.3389/fvets.2023.1220213 Received 15 May 2023 Accepted 17 July 2023 Published 10 August 2023 Volume 10 - 2023 Edited by Huansheng Yang, Hunan Normal University, China Reviewed by Dan Yi, Wuhan Polytechnic University, China