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Formulation strategies that extend nasal residence time or enhance epithelial transport may also facilitate dose reduction while preserving therapeutic efficacy (Illum, 2003

The resulting library was subjected to several positive and negative selection cycles following a published procedure 31

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Klimmek R, Krettek C, Szinicz L, Eyer R, & Weger N (1983) Effects of biotransformation of 4-dimethylaminophenol in man and dogs

Because B12 is a water-soluble vitamin, the body typically uses what it needs and excretes the rest