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As a result of its ability to inhibit the expression of transcription factors and pro-inflammatory cytokines such as TNF-, IL-1, IL-6, IL-8, IL-12, IL-1, and monocyte chemoattractant protein-1 (MCP-1), curcumin has demonstrated anti-inflammatory properties ( Supplementary Table 1 )

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Vessel responses to increasing concentrations of SNP (10 9 M-10 6 M) were also determined to assess vascular smooth muscle sensitivity to NO

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