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Smith Journal of Pediatric Orthopaedics .2024

This can affect the production of pro-inflammatory cytokines by macrophages, increase the autophagic activity of macrophages, and induce the generation of antimicrobial products, including cathelicidin and -defensin [94]

Topical formulations are also available for skin-focused applications, but injectable delivery achieves higher tissue concentrations and is the standard for clinical protocols