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Together, these results strongly suggested that the consumption of GSH is essential for enhancing CDDP chemosensitivity, which also explained the superior therapeutic effect of CDCZA nanoparticles in vitro

Fotiou P, Raptis A, Apergis G, Dimitriadis G, Vergados I, Theodossiadis P

Free radical derivatives formed from cyclooxygenase-catalyzed dihomo-gamma-linolenic acid peroxidation can attenuate colon cancer cell growth and enhance 5-fluorouracils cytotoxicity

The DAC molecule has a milder version of the same problem, not an exemption from it: at 5001,000 mcg twice weekly a 5 mg vial is consumed in 2.55 weeks, but at the 300400 mcg low end of its documented range the same vial takes 68 weeks also far outside a 12 week reconstituted window