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The proteins accumulate postsynthetic modifications, especially resulting from oxidation, leading to formation of protein aggregates that scatter light

Exercise activates this pathway through ROS-mediated mechanisms, and the two may have synergistic or additive effects (Tkaczenko and Kurhaluk, 2025)

Lie et al

Additionally, while muscle protein breakdown is stimulated during exercise, protein synthesis is increased during recovery through ROS signaling [102]

They further explained that no appropriate clinical APC exists for this procedure and note that it has very low Medicare utilization rates upon which to base a clinical APC assignment