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Studies demonstrate that esculin (50-200 mol/l) can disrupt the interaction of the Kelch-like ECH-associated protein 1 (Keap1), a key negative regulator of the Nrf2 signaling pathway, with Nrf2 to activate the Nrf2 signaling pathway (54,55)

Herbal prescriptions Kanglaite injection and Kushen injection have been found in clinical trials to reduce the hepatotoxicity of CDDP significantly and are expected to be used as adjunctive therapies with CDDP [55, 75, 76]

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EGCG exerts growth inhibitor effort on human cancer cell lines without affecting normal cells of the body

It is noteworthy that the age-old Hippocratic belief that all disease originates in the gut remains relevant in modern neurobiology, with growing evidence supporting the importance of the gut-brain axis in maintaining neural well-being (130)