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Intracellular CySS is then reduced to cysteine (Cys) by NADPH

In extracellular Ca 2+ -depleted medium (Figure 2E) or in the presence of 100 M lanthanum ions (La 3+ ), a non-selective calcium channel blocker, tBuOOH-induced [Ca 2+ ] i accumulation was completely inhibited (not shown), suggesting the occurrence of Ca 2+ entries under oxidative conditions

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This may include antihistamines to ease itching, corticosteroids to reduce inflammation, or epinephrine for more serious symptoms

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