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In fact, the activities of both APR and SAT have been shown to increase during oxidative stress

B vitamins and the brain: Mechanisms, dose and efficacy--A review

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The method of reducing the single dose with the same total dose can make pharmacokinetics safer, lower trough concentration, and reduce the accumulation of cisplatin in the inner ear ( Pedmark, a sodium thiosulfate (STS) formulation, is the first and only novel drug approved by the US FDA to prevent the risk of cisplatin ototoxicity in children aged 1 month and older with localized non-metastatic solid tumors

doi: 10.1016/j.apsb.2019.07.001