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At both cellular and organismal levels, UVB exposure enhances the expression of DNMTs, including DNMT1/2/3, and reduces the expression of TETs, including TET1/2/3, leading to hypermethylation of COL4A1 promoter CpG islands and subsequent inhibition of COL4A1 expression (285)

Pearce MJ, Mintseris J, Ferreyra J, Gygi SP, Darwin KH

(1992) Importance of growth hormone for the induction of hepatic low density lipoprotein receptors

Moreover, sporadic and temporally disjointed inflammation can cumulatively exacerbate harm to HSC function, leading to a series of aging-related changes at both the molecular and cellular levels in HSCs 25

Vitamin A plays a role in regeneration of mucous tissue and skin which in turn enhances the barrier against invading pathogens [104, 105]