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When intermittent doses are given, the loading dose calculated from equation (12) will only reach the average steady-state concentration and will not match the peak steady-state concentration ( Figure 36 )

Oral bioavailability studies would require dose-escalation trials measuring plasma concentrations after oral dosing versus subcutaneous dosing those trials have not been conducted or published as of 2026.

In recent years, B12 shots have become increasingly popular, apparently favoured by such big-name stars as Charlize Theron, Justin Timberlake, and Madonna

This is reasonable for pharmaceutical-grade product