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Both activation of the G-protein-coupled receptor GPR35 (Berlinguer-Palmini et al., The concepts of acute and chronic glutamate toxicity The term excitotoxicity was first used by Olney (1986) to describe the ability of L-glu, as well as structurally related amino acids, to kill nerve cells, a process that has been proposed to take place not only in acute but also chronic diseases of the central nervous system (for reviews Choi, 1990)