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In addition to the role mentioned above in the process of oxidative stress, the GPX family also plays a unique role in tumor development ( Statements Author contributions All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication

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k , Schematic of cystine stable-isotope labeling approach for metabolomics and proteomics

Folic acid is used in food fortication, inhibits lipid peroxidation, and is an eective free radical scavenger [90]

Similarly, anti-angiogenic therapy could also improve the antitumor functions of cytokine-induced killer cells (CIK cells) cells by normalizing tumor vasculature and alleviating the hypoxic TME, as shown in NSCLC xenografts [143]