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Unlike ordinary freckles in these locations, these lesions are not related to sun exposure, and are considered virtually pathognomonic of NF-1 (Crowes sign)

CrossRef Receptor for the Advanced Glycation End Products (RAGE) Pathway in Adipose Tissue Metabolism Klaudia Gutowska, Krzysztof Czajkowski, Alina Kuryowicz International Journal of Molecular Sciences.2023