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Inflammation usually elevates KP and its activity has been shown to mediate immune suppression, oxidative stress and most importantly NAD + starvation

RT-PCR was done using a standard SYBR-green PCR kit (SYBR Premix EX TaqTM II, Takara), and the gene-specific PCR amplification was conducted using the Applied Biosystems StepOnePlus Real-Time PCR System (Applied Biosystems, USA)