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The effect is not usually instantaneous

Inflammatory bowel diseases, which include ulcerative colitis and Crohns disease, are chronic diseases with an incompletely understood etiology [95, 96]

JBIC Journal of Biological Inorganic Chemistry, 24 (7), 929941

An example of such amino acid substitution is the replacement of N297 by a glycine or an alanine

Research staff for this project administer an interview to participants to collect dietary and demographic information and medical, dental, and laboratory tests to collect physiologic measures