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van Dijk, A

Many basic events of cell regulation such as protein phosphorylation and binding of transcription factors to consensus sites on DNA are driven by physiological oxidant- antioxidant homeostasis, especially by the thiol-disulfide balance

In addition, NF-B response was significantly reduced in CLOCK -deficient cells and in the tissues of CLOCK -knockout mice 71 , thus supporting the notion that CLOCK might act as a positive regulator of NF-B transcriptional activity

This doesnt mean avoiding supplements altogether

Many energy drinks, protein bars, and meal replacement shakes contain high doses of B12 (sometimes 2,000 to 5,000% of the Daily Value per serving)