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SSRIs, 5-HT4 partial agonists, 5-HT6 antagonists prevent both cognitive deficits and AD neuropathology and SSRIs increase A clearance in transgenic AD mouse models and humans [126,127,128,129,130,131,132,133,134]

The low catalytic efficiency, pH value and high level of glutathione (GSH) in TME limit the antitumor application of traditional Fe 2+ -mediated Fenton reaction

Cultures were incubated at 37 C under a controlled atmosphere of 5% CO 2 , 5% O 2 , and 90% N 2

While curcumin exerts anti-inflammatory effects by negatively regulating the expression of Hsp60 through HSF1, HTX has been shown to suppress NF-B activation and reduce the production of proinflammatory cytokines such as IL-1 and TNF- in microglial cells

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