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Machine learning empowered formulation design, optimization and characterization of nanoparticulate drug delivery systems: current applications, challenges, and future perspectives

3.3 Mechanical stress and ECM remodeling Throughout the initiation and progression of pulmonary fibrosis, mechanical stressan essential exogenous biophysical cueis regarded as a pivotal regulator of epithelial-to-mesenchymal transition (EMT) and fibrotic tissue expansion ( Experimental data demonstrate that sustained mechanical stretch activates the TGF-/Smad axis, suppresses E-cadherin, and elevates mesenchymal markers such as Vimentin and Snail, thereby driving alveolar epithelial cells toward a mesenchymal phenotype

The researchers measured how many of the participants neutralizing antibodies were specific for the original variant, the omicron variant or both

The use of an optimised internal standard minimises any analytical variations that could be crucial when calculating the GSSG/GSH ratio