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The smoking-associated chronic inflammation could induce squamous metaplasia and facilitate oncogenesis and metastasis based on the accumulation of genetic changes such as TP53 and AKR1B10 [30,31,32,33]

These data could explain, at least in part, why we found lower eGFR levels in relation to the GCLC rs1555903 SNP in the non-exposed but not in the exposed group (Table 4)