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Clin Lymphoma Myeloma Leuk 13(2):153-8, 2013

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Moreover, the metabolite markers associated with responders and non-responders to metformin are not clearly established as either a cause or an effect of genetic alterations on the pharmacokinetics of metformin ( As previously discussed, metformin users have heterogeneous response to hyperglycemia in diabetes patients ( Pharmacomicrobiomics The gastrointestinal tract is home to a varied and dynamic colony of bacteria known as the gut microbiota, which has a major influence on human health and disease ( Gut diversity as a marker for metformin responsiveness Microbes can influence drug pharmacokinetics through mechanisms such as activation, competition, biodegradation, and potentiation

33,34 In addition, compared to other stem cell types, DPSCs proliferate more rapidly 33 and can resist lipopolysaccharide-induced oxidative stress and cellular senescence in the periodontitis microenvironment, making them particularly effective for inducing periodontal regeneration

Animal and cell studies show promise in areas like fertility and ovarian support, yet human trials remain sparse