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Acute sensory neuropathy-neuronopathy from pyridoxine overdose

350 Mitochondrial dysfunction in Schwann cells triggers alterations in lipid metabolism, leading to myelin sheath dysfunction and accumulation of toxic lipid intermediates, which cause axonal degeneration and neuropathy

For mechanism, the antioxidant properties of vitamin E are linked to improvements in serum paraoxonase-1 activity and some metabolic factors in patients with type 2 diabetes, although they did not significantly affect nitrite/nitrate levels

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[DOI] [PubMed] [Google Scholar] 153.Mizushima N, Levine B, Cuervo AM, Klionsky DJ