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APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

Overload of mitochondria with ammonium instigates over-production of reactive oxygen species and opening of mitochondrial permeability transition pore, which further damages astrocytes and induce astrocyte swelling

2.2 Data acquisition MRI: All data were collected on a Philips 3T Ingenia Elition RX scanner (Philips Healthcare, Best, the Netherlands) equipped with a 32-channel receive-only head coil

Improved Skin Texture: Reduces inflammation and promotes cell turnover, leading to smoother and more radiant skin

In contrast, miR-101 is highly expressed in M2 macrophages (pro-tumor) and suppresses C/EBP and KLF6, promoting M1-to-M2 polarization