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foxo4-dri peptide senolytic human trial

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Following co-culture for 48 h, with GMSCs either in the trans-well or encapsulated in the 3D-collagen hydrogel, THP-1 macrophages displayed elongated cellular morphology characteristic of a pro-regenerative M2-like phenotype [44, 45]

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The prevalence of these effects is currently unknown, and they are not commonly listed as adverse effects in US prescribing information for most agents

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These findings suggest a possible role for both compounds in supporting angiogenic responses in experimental models

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