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For example, the HPH model only reflects the pathological characteristics of hypoxia-induced PH, and cannot simulate the core disease characteristics of PAH such as the genetic background of IPAH (e.g., BMPR2 mutation) and the hemodynamic abnormalities of CHD-PAH, making it difficult to fully reveal the regulatory rules of UPS in PAH

Via the same physics that govern HEPA filtration, they are even more efficient at capturing both larger and smaller particles

Incidence rates of MACE+ and all-cause mortality for all randomized subjects exposed to at least 1 partial dose of study treatment in the parent study are shown for all treatment groups during treatment, and through end of study in the Table 19 below