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The soluble interleukin 6 receptor: advanced therapeutic options in inflammation

doi: 10.5858/arpa.2017-0257-ra 34 Della-TorreERigamontiEPeruginoCBaghai-SainSSunNKanekoNet al

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Isotopologue ratios from our [U- 13 C]glucose tracing experiments are consistent with SAAR increasing TCA cycle anaplerosis through PC (i.e., the generation of OAA from pyruvate) and the resulting OAA being preferentially directed to asparagine rather than flux through the TCA cycle