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Discussion Unbalanced interactions between immune cells and epidermal keratinocytes cause psoriasis, which can be defined by keratinocyte differentiation, abnormal growth, and inflammation [42, 43]

Theoretical Risks with Chronic Use Some concerns raised by clinicians and researchers include: Unregulated angiogenesis: Overstimulation of blood vessel growth could hypothetically support tumor progression in cancer-prone individuals Unknown hormonal crosstalk: While BPC-157 is non-hormonal, it interacts with systems (e.g., nitric oxide, dopamine) that may influence downstream signaling Immune tolerance or desensitization: Chronic exposure to any peptide could alter immune recognition or receptor sensitivity over time These concerns are theoretical , but they highlight why BPC-157 should not be used indefinitely or in uncontrolled cycles

Acta Naturae 6:4047 Czeredys M, Maciag F, Methner A, Kuznicki J (2017) Tetrahydrocarbazoles decrease elevated SOCE in medium spiny neurons from transgenic YAC128 mice, a model of Huntingtons disease

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