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Interestingly, the screening revealed the existence of an allosteric pocket close to the NADPH binding site, named the doorstop pocket since ligands binding at this site interfere with TR activity by hampering the opening movement needed to allow cofactor binding

Data Availability The datasets generated during the current study are available from the corresponding author on reasonable request

Levofloxacin persisters (levopersisters) were quantified as CFU/mL, and minimum inhibitory concentrations (MICs) were assessed using the broth microdilution method, following the Clinical and Laboratory Standards Institute (CLSI) guidelines [21]