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People who cant metabolize codeine efficiently, also cant metabolize dexromethorphan (Robitussin cough suppressant) well, and can become impaired on it on suffer dissociative reactions

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This decline can compromise liver function, leading to various health concerns, including non-alcoholic fatty liver disease (NAFLD) and other liver-related disorders

Consequently, hepatocytes attempt to repair cellular damage through increased autophagy and mitophagy, which ultimately fails [2]

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