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The dimerization issue: GST naturally forms homodimers

The extracellular matrix as modifier of neuroinflammation and remyelination in multiple sclerosis

doi: 10.1016/j.rbmo.2016.10.008 208 AgarwalARoychoudhurySBjugstadKBChoC-L

Notably, fer-1 rescues completely the cell-killing activity of ML210 but not that of either RSL3 or ML162 (Figure 1E), suggesting that if ML210 is indeed a direct inhibitor of GPX4, it could prove much more selective than chloroacetamide inhibitors (Figure 1E)