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This amplifies the ATF4/CHOP/ChaC1 cascade under ER stress, resulting in decreased intracellular GSH and cysteine, increased intracellular ROS, redox homeostasis disruption, secondary oxidative stress in cancer cells and selective ferroptosis of cancer cells (66,100)

baicalensis resulted in more significant reductions in blood glucose and serum cholesterol levels compared to metformin alone, without adversely affecting the pharmacological actions of metformin ( S

The table shows the values of the constants we assigned to each of the metabolites that were originally variables in the Reed-Nijhout model

doi: 10.1080/21548331.1997.11443469

10.1016/j.bbi.2023.11.019 18 ChenT.ChengL.MaJ.YuanJ.PiC.XiongL.et al (2023)