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From a peri-implant health standpoint, this signal is clinically meaningful because the early healing window represents a biologically vulnerable period: inadequate primary stability, micromotion, and delayed interfacial bone formation can amplify marginal remodeling and increase inflammatory susceptibility in the peri-implant compartment

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This is the full report of a randomized, open-label, active-controlled, dose-finding Phase IIb study to evaluate the efficacy and safety of trabedersen (AP12009) administered intra-tumourally by convection-enhanced delivery in patients with recurrent or refractory high-grade glioma

The included variables were vancomycin prescription days, maximum daily antibiotic dose, serum creatinine levels before and 48 h after vancomycin infusion, vancomycin serum level, weight, CCI determined at patient admission, gender, ethnicity, age, use of noradrenaline, use of nephrotoxic drugs, and mortality during hospitalization