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Specifically, in Tbx1 +/ mice, we observed down-regulation of adenosine, niacinamide (vitamin B3), methanol, phosphoethanolamine, glutamine, leucine, glycerophospholipidssphingomyelin (from the lipophilic fraction), and taurine, and up-regulation of inosine, short-chain fatty acids, acetate, glutamate, myoinositol, and dimethylglycine (Figs 2C and S3, Table S1)

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