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Over time, the duration and frequency of these flares may increase, resulting in chronic gouty arthritis and subcutaneous deposits of crystals, referred to as tophi, both of which can lead to the destruction of joints and musculoskeletal disability

The regulatory requirements for the application are in general covered by the requirements for conventional medicinal products and may have to apply for a full Sweden market authorisation when the application concerns a plant that has not been previously authorized on the market [76]

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Clinical Pharmacology of Phenylephrine: Mechanism and Applications

Circ Res 85:357363