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32b and c)

NAC, on the other hand, has no direct relationship to NAD+ productionit supports glutathione synthesis and antioxidant defense

In the presence of normal levels of ROS, the expression of Nrf2 is controlled by the Kelch-like ECH-associated protein 1 (Keap 1), which targets Nrf2 to ubiquitin-mediated degradation in the cytoplasm

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It is important to note that the group treated with melatonin alone did not show any significant changes in the biomarkers listed above, compared to the control group, at the given dose of melatonin