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MK-801, a noncompetitive antagonist of the NMDA-type glutamate receptor, was found to worsen the behavioral phenotypes in this mouse (McGrath et al., 2000)

Consider: daily multivitamin, vitamin D 2,000-4,000 IU daily (most people are deficient), vitamin B12 if energy is low, calcium 1,000-1,200mg daily (especially for women), fiber supplement if constipated, protein powder if struggling to hit 80-100g daily from food

But midlife wellness is more nuanced than that, and there are multiple reasons why you could feel off on any given day

Her takeaway thought was the need for a guaranteed annual income. Sylvias complaint is that her eyes are down the tubesa real drag. She adds, No more tree climbing