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But even the highest-quality product might cause skin flushing, hives, or rashes

By inhibiting NNMT, the body maintains higher NAD levels, which in turn activate SIRT1, a longevity-associated gene, which may improve mitochondrial activity, fat oxidation, insulin sensitivity, and by overall energy balance

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Clinical Update 11/23/2023 Headache, Alcohol, and Quercetin Quercetin may put one at risk for headache and facial flushing when drinking alcohol, according to recent research

That is roughly triple the placebo response, which sounds impressive until you consider the absolute numbers