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In the cardiovascular context, DAMPs release from ferroptotic cardiomyocytes or endothelial cells activates resident macrophages, recruits circulating monocytes and neutrophils, and stimulates the production of inflammatory cytokines such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), and interleukin-6 (IL-6)

Crocetin protected human hepatocyte LO2 cell from TGF--Induced oxygen stress and apoptosis but promoted proliferation and autophagy via AMPK/m-TOR pathway

doi: 10.21037/atm-21-1595 12 DixonSJLembergKMLamprechtMRSkoutaRZaitsevEMGleasonCEet al

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AIFM2 blocks ferroptosis independent of ubiquinol metabolism