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Acetyl-L-Carnitine in Neuropathic Pain

Regarding the treatment of this disease, in 1993, Gibson et al

All subjects reported to the lab for testing, on both days, in a 10-hour fasted state

This increases the concentration of malonyl-CoA, the first intermediate in fatty acid synthesis, leading to the inhibition of carnitine acyltransferase 1, thereby preventing fatty acid entry into the mitochondrial matrix for oxidation