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This mechanism underlies its anesthetic, analgesic, and antidepressant properties

58 In Iran, a study reviewing tramadol 600 mg daily vs methadone 60 mg daily to manage OWS over 3 days resulted in similar OOWS scores and drop-out rates

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201 Using a specific TP receptor antagonist and genetic editing of animals, Egan et al 202 revealed that COX-1 promoted early atherosclerosis and thrombosis by mediating TXA2 production and the downstream activation of the TP pathway