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Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, et al

5Halliwell B, Gutteridge JMC

Using X-ray structures of dDAT (Supplementary Table 1) in complex with popularly prescribed inhibitors of chronic pain including S -duloxetine, milnacipran, and a synthetic opioid, tramadol, we identify the importance of subsite C as the major determinant of inhibitor specificity between NET and DAT