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Results Oral administration of low-dose carbon monoxide reduces dopamine cell loss in an -synuclein rat model of Parkinsons disease To investigate the neuroprotective potential of CO, we employed a genetic model of PD in which an adeno-associated virus (AAV) drives the overexpression of mutant A53T human Syn in the SNpc of rats, resulting in the unilateral loss of dopaminergic neurons after 21 days 21

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